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topotecan hydrochloride tpt  (MedChemExpress)
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MedChemExpress topotecan hydrochloride tpt
Topotecan Hydrochloride Tpt, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/topotecan/Topotecan+hydrochloride/pm42261811-317-0-6
Average 94 stars, based on 1 article reviews
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topotecan hydrochloride  (Tokyo Chemical Industry)
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Tokyo Chemical Industry topotecan hydrochloride
Schematic representation of casting of the <t>topotecan-loaded</t> MSP. MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.
Topotecan Hydrochloride, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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topotecan  (Sandoz)
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Schematic representation of casting of the <t>topotecan-loaded</t> MSP. MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.
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https://www.bioz.com/product/topotecan/topotecan/pm42288516-271-4-5
Average 86 stars, based on 1 article reviews
topotecan - by Bioz Stars, 2026-09
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topotecan  (MedChemExpress)
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MedChemExpress topotecan
Schematic representation of casting of the <t>topotecan-loaded</t> MSP. MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.
Topotecan, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/topotecan/Topotecan/custom%40hy-13768a%4042242225
Average 94 stars, based on 1 article reviews
topotecan - by Bioz Stars, 2026-09
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irinotecan  (MedChemExpress)
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MedChemExpress irinotecan
NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, <t>Irinotecan,</t> Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)
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Average 94 stars, based on 1 article reviews
irinotecan - by Bioz Stars, 2026-09
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topotecan  (Novartis)
86
Novartis topotecan
NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, <t>Irinotecan,</t> Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)
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Average 86 stars, based on 1 article reviews
topotecan - by Bioz Stars, 2026-09
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topotecan  (Glaxo Smith)
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Glaxo Smith topotecan
NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, <t>Irinotecan,</t> Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)
Topotecan, supplied by Glaxo Smith, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/topotecan/topotecan/us12599678-1439-38-40
Average 86 stars, based on 1 article reviews
topotecan - by Bioz Stars, 2026-09
86/100 stars
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topotecan  (Selleck Chemicals)
94
Selleck Chemicals topotecan
NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, <t>Irinotecan,</t> Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)
Topotecan, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/topotecan/Topotecan+HCl/bio_rxiv__64898__2026__01__31__703021-181-20-35
Average 94 stars, based on 1 article reviews
topotecan - by Bioz Stars, 2026-09
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Image Search Results


Schematic representation of casting of the topotecan-loaded MSP. MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Schematic representation of casting of the topotecan-loaded MSP. MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques:

Representative digital images of the master mold (A) , PDMS mold (B) , and stereomicroscopic images of the topotecan MSP at different magnifications (C and D) , scanning electron microscopic images of the topotecan MSP (E) . MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Representative digital images of the master mold (A) , PDMS mold (B) , and stereomicroscopic images of the topotecan MSP at different magnifications (C and D) , scanning electron microscopic images of the topotecan MSP (E) . MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques:

Force-displacement curves obtained after compression test of blank and topotecan MSP (A) , and insertion test of blank and topotecan MSP into the excised goat sclera (B) . MSP = microneedle scleral patch.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Force-displacement curves obtained after compression test of blank and topotecan MSP (A) , and insertion test of blank and topotecan MSP into the excised goat sclera (B) . MSP = microneedle scleral patch.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques:

Representative Fourier-transform infrared spectra (A) , powder X-ray diffraction peak pattern (B) , differential scanning colorimetry thermograms (C) , and thermogravimetry analysis thermograms (D) of pure topotecan HCl, sodium hyaluronate, physical mixture (topotecan HCl + sodium hyaluronate), and topotecan MSP. The physical mixture was prepared with topotecan HCl: sodium hyaluronate ratio same as that in topotecan MSP. MSP = microneedle scleral patch.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Representative Fourier-transform infrared spectra (A) , powder X-ray diffraction peak pattern (B) , differential scanning colorimetry thermograms (C) , and thermogravimetry analysis thermograms (D) of pure topotecan HCl, sodium hyaluronate, physical mixture (topotecan HCl + sodium hyaluronate), and topotecan MSP. The physical mixture was prepared with topotecan HCl: sodium hyaluronate ratio same as that in topotecan MSP. MSP = microneedle scleral patch.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques: Fourier Transform Infrared Spectroscopy, Colorimetric Assay

Scanning electron microscopic images of in vitro dissolution of topotecan MSP at different time points of 0 second, 5 seconds, 10 seconds, 15 seconds, 20 seconds, and 25 seconds. MSP = microneedle scleral patch.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Scanning electron microscopic images of in vitro dissolution of topotecan MSP at different time points of 0 second, 5 seconds, 10 seconds, 15 seconds, 20 seconds, and 25 seconds. MSP = microneedle scleral patch.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques: In Vitro, Dissolution

Cumulative amount of topotecan permeated across the excised goat sclera after administration of the MSP and topotecan solution. Asterisk (∗) represents that the value is significantly different at P < 0.05 compared with topotecan solution. MSP = microneedle scleral patch.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Cumulative amount of topotecan permeated across the excised goat sclera after administration of the MSP and topotecan solution. Asterisk (∗) represents that the value is significantly different at P < 0.05 compared with topotecan solution. MSP = microneedle scleral patch.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques:

Ex vivo distribution of topotecan in various ocular tissues after application for 1 hour (A) and 4 hours (B) . MSP = microneedle scleral patch.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Ex vivo distribution of topotecan in various ocular tissues after application for 1 hour (A) and 4 hours (B) . MSP = microneedle scleral patch.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques: Ex Vivo

Topotecan distribution in different ocular tissues in rabbit eyes at different time points, including 1 hour (A) , 2 hours (B) , and 8 hours (C) , after intravitreal injection and MSP application. MSP = microneedle scleral patch.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Topotecan distribution in different ocular tissues in rabbit eyes at different time points, including 1 hour (A) , 2 hours (B) , and 8 hours (C) , after intravitreal injection and MSP application. MSP = microneedle scleral patch.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques: Injection

Retinal fundus images of rabbit ocular model before and after application of topotecan MSP. MSP = microneedle scleral patch.

Journal: Ophthalmology Science

Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

doi: 10.1016/j.xops.2026.101226

Figure Lengend Snippet: Retinal fundus images of rabbit ocular model before and after application of topotecan MSP. MSP = microneedle scleral patch.

Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

Techniques:

NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, Irinotecan, Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)

Journal: Cancer Cell International

Article Title: NUDT1 drives osteosarcoma progression and serves as a robust predictor of clinical outcomes

doi: 10.1186/s12935-026-04347-7

Figure Lengend Snippet: NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, Irinotecan, Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)

Article Snippet: Topotecan (#HY-13768) and Irinotecan (#HY-16562) were purchased from MedChemExpress.

Techniques: Expressing, In Vitro, Biomarker Discovery